What Is Delta-12 Protoglandin J in Regard to Cancer?
Question by Kevin7: What is delta-12 protoglandin J in regard to cancer?
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Answer by Tiny
Delta-12 Prostaglandin–you mispelled “prostaglandin” should anyone else want to answer this. I am unfamiliar with this but will look for some info on it. đŸ™‚
Answer by Rajinder
I found complete relief from very painful sinus by giving up water and other liquids for 48 hours. That was 3 years back and no sinus since then. Earlier I used to get sinus 2-3 times in a year with extreme body pain and fever of 105. There was an additional factor. For last 2-3 years I was drinking 1 glass of water 1 hour before each meal and no other water or liquids during the day.
The logic for this sinus relief is as under –
There is swelling and inflamation during sinus. Water reduction will cause fast relief from swelling. That will make it easier and faster to get rid of cough.
Water reductions boosts the immune system by increasing the blood acids by upto 10% of previous levels.
Since then I tried the same approach on lot of other ailments – like renal failure, slip disk, dry skin, dandruff, constipation, mouth ulcers, dry eye syndrome etc. The result were shocking.
I had been wearing spectacles since the age of 15 i.e. for last 34 years. I have been trying eye exercises since begining with practically no benefits. Last 3 months I started eye exercises in a different way. It gave benefits in a number of areas. Better concentration and memory, better digestion, clearing of dark eye circles, no head aches etc. In 15 days I could cure my + number. There is marked improvement in other parameters. The – number seems to be coming down but I have not checked.
I wonder that cough effects every nerve in the nearby area. Food pipe is also close by. So it effects that as well. All mental problems also arise because of excess water. I am quite hopeful that drinking water and liquids on alternate days and giving up water and liquids on other days as a way of recovery from cancer and all other diseases. Eye exercises is additional way of speeding up recovery from cancer and other diseases.
Dark eye circles are caused due to nasal congestion.
Dark eye circles are also due to gluten intolerance and celiac diseases.
That is a clear indication that cough effects eye muscles, brain, entire gastric system and could be responsible for cancer as well. Linking cough with cancer may seem to be a bit far fetched. But there are lot of other things which I am not able to share at yahoo answers because of limitations to number of charaters that I can post here.
General Guidelines –
Give up water and all other liquids for 24 hours. To avoid dehydration keep indoors. In case of cancer repeat this after every 24 hours.
On other days drink 1 glass of water 1 hour before each meal. The total water intake on these days should not be more than 3 glasses.
There are 3 main or rather only common symptoms of cancer –
1) The cells are not able to produce 38 units of energy that is done in case of normal cells.
2) The stomach acid is very low.
3) Tumours or general swelling.
The reason and logic for the above in short is as under –
The cells of the human body are at the lowest level of producing energy. To produce energy cells burn glucose in presence of oxygen.
When there is more water in the cell then the energy producing capacity of the cell is significantly reduced. Reduced energy by the cells cause build up of water outside the cells as well. That causes pain in the entire body due to constant excess weight on the cells.
Continued less burning of glucose also causes accumulation of other minerals in the cell. That causes the cells to swell up.
This does not happen overnight.
There are various checks in the body to avoid build up of water in the cells. Like whenever there is change in atmosphere temperature the body adjusts the amount of water that cells carry. When this adjustments fails due to some reason the body tries various modes to get rid of the excess water – sinus, cold and cough, adrelin levels, water reduction thru increased urine etc.
There are certain other complications that happen due to build up of excess water in the cells. One is build up of bacteria and infections in the body.
These bacteria or infections cause the increase in the body temperature. The increased temperature takes care of the situation.
What is the reason for cancer. Same. There are tumours in all kind of cancers. The tumours are caused due to cells not dieing. The reason for cells not dieing is cells not producing enough energy and that prolongs their life cycle.
What is the cure for cancer. The cure for cancer and all other common ailments is same. I found that sinus, cold, cough, IBS, skin blood clots, slip disk, dry skin, mouth ulcers, renal failure etc can be cured effectively by giving up water and all other liquids for 24 hours to 48 hours. This has been tested on more than 50 persons so far. Thru Yahoo Answers this same been tested on more than 100 people but I do not have conclusive proof of this. The cerainity with which relief is produced in 24 hours gives enough hope for cancer cure in 15 days.
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This is, indeed, good news!
Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA.
Abstract
Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. We show here that ?(12)-PGJ(3), a novel and naturally produced CyPG from the dietary fish-oil ?-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA; 20:5) alleviates the development of leukemia in 2 well-studied murine models of leukemia. IP administration of ?(12)-PGJ(3) to mice infected with Friend erythroleukemia virus or those expressing the chronic myelogenous leukemia oncoprotein BCR-ABL in the hematopoietic stem cell pool completely restored normal hematologic parameters, splenic histology, and enhanced survival. More importantly, ?(12)-PGJ(3) selectively targeted leukemia stem cells (LSCs) for apoptosis in the spleen and BM. This treatment completely eradicated LSCs in vivo, as demonstrated by the inability of donor cells from treated mice to cause leukemia in secondary transplantations. Given the potency of ?-3 polyunsaturated fatty acid-derived CyPGs and the well-known refractoriness of LSCs to currently used clinical agents, ?(12)-PGJ(3) may represent a new chemotherapeutic for leukemia that targets LSCs.
http://www.ncbi.nlm.nih.gov/pubmed/21967980
Penn State Research Offers Hope for Leukemia Cure
A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers.
The compound — delta-12-protaglandin J3, or D12-PGJ3 — targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, said Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences. The compound is produced from EPA — Eicosapentaenoic Acid — an Omega-3 fatty acid found in fish and in fish oil, he said.
“Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants, but we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing stem cells in mice,” said Prabhu. “The important thing is that the mice were completely cured of leukemia with no relapse.”
The researchers, who released their findings in the current issue of Blood, said the compound kills cancer-causing stem cells in the mice’s spleen and bone marrow. Specifically, it activates a gene — p53 — in the leukemia stem cell that programs the cell’s own death. “p53 is a tumor suppressor gene that regulates the response to DNA damage and maintains genomic stability,” Prabhu said. Killing the stem cells in leukemia, a cancer of the white blood cells, is important because stem cells can divide and produce more cancer cells, as well as create more stem cells, Prabhu said.
The current therapy for CML extends the patient’s life by keeping the number of leukemia cells low, but the drugs fail to completely cure the disease because they do not target leukemia stem cells, said Robert Paulson, associate professor of veterinary and biomedical sciences, who co-directed this research with Prabhu.
“The patients must take the drugs continuously,” said Paulson. “If they stop, the disease relapses because the leukemia stem cells are resistant to the drugs.” Current treatments are unable to kill the leukemia stem cells, Paulson said. “These stem cells can hide from the treatment, and a small population of stem cells give rise to more leukemia cells,” said Paulson. “So, targeting the stem cells is essential if you want to cure leukemia.”
During the experiments, the researchers injected each mouse with about 600 nanograms of D12-PGJ3 each day for a week. Tests showed that the mice were completely cured of the disease. The blood count was normal, and the spleen returned to normal size. The disease did not relapse. In previous experiments, the compound also killed the stem cells of Friend Virus-induced leukemia, an experimental model for human leukemia. The researchers focused on D12-PGJ3 because it killed the leukemia stem cells, but had the least number of side effects. The researchers currently are working to determine whether the compound can be used to treat the terminal stage of CML, referred to as Blast Crisis. There are currently no drugs available that can treat the disease when it progresses to this stage.
http://live.psu.edu/story/56944